Microbiota and T Cell Immunity

Grant number: 1124815 | Funding period: 2017 - 2019

Completed

Abstract

Our research has identified unprecedented communications between the microbes that colonize our body’s surfaces and killer T cell immunity. Our findings indicate that microflora is key to a healthy balance between two immune mediator systems that have opposing effect on T cell immunity. The project will extend our understanding of how this regulated and seeks to harness these novel insights to explain the well known, but poorly understood role of microbes in autoimmune diseases.

Related publications (5)

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CD4 T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses

EG Bawden, T Wagner, J Schröder, M Effern, D Hinze, L Newland, GH Attrill, AR Lee, S Engel, D Freestone, M de Lima Moreira, E Gressier, N McBain, A Bachem, A Haque, R Dong, AL Ferguson, JJ Edwards, PM Ferguson, RA Scolyer

2024-01-19

Whereas CD4<sup>+</sup> T cells conventionally mediate antitumor immunity by providing help to CD8<sup>+</sup> T cells, recent cli..

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CD4 T cell calibration of antigen-presenting cells optimizes antiviral CD8 T cell immunity

E Gressier, J Schulte-Schrepping, L Petrov, S Brumhard, P Stubbemann, A Hiller, B Obermayer, J Spitzer, T Kostevc, PG Whitney, A Bachem, A Odainic, C van de Sandt, THO Nguyen, T Ashhurst, K Wilson, CVL Oates, LJ Gearing, T Meischel, K Hochheiser

2023-06-01

Antiviral CD8<sup>+</sup> T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells ..

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Microbial Metabolites in the Maturation and Activation of Dendritic Cells and Their Relevance for Respiratory Immunity

KR Wilson, E Gressier, MJ McConville, S Bedoui

2022-07-08

The respiratory tract is a gateway for viruses and bacteria from the external environment to invade the human body. Critical to th..

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Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8 T Cells

A Bachem, C Makhlouf, KJ Binger, DP de Souza, D Tull, K Hochheiser, PG Whitney, D Fernandez-Ruiz, S Dähling, W Kastenmüller, J Jönsson, E Gressier, AM Lew, C Perdomo, A Kupz, W Figgett, F Mackay, M Oleshansky, BE Russ, IA Parish

2019-08-20

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

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Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

T Gebhardt, U Palendira, DC Tscharke, S Bedoui

2018-05-01

A large proportion of memory T cells disseminated throughout the body are non-recirculating cells whose maintenance and function i..

University of Melbourne Researchers